MP Model (Vancomycin): 381 fits, generated 2026-08-26 14:32 UTC
by marshall.
Two-Compartment Models: 371 fits, generated 2026-08-26 14:33 UTC.
This page displays key performance metrics from institutional pharmacokinetic modeling datasets.
Identical metrics computed across all 1-compartment fittings for comparison with the Goti 2-compartment results above.
Identical metrics computed across all 1-compartment fittings for comparison with the Carreno 2-compartment results above.
N = 371 % Male = 53.9% (n = 371 with sex recorded)
| Variable | Mean | SD | Median | Range | N |
|---|---|---|---|---|---|
| Age (yr) | 65.9 | 16.1 | 68.0 | 22.0 – 99.0 | 371 |
| Height (in) | 67.3 | 4.4 | 67.0 | 56.0 – 77.0 | 371 |
| Weight (kg) | 84.6 | 29.5 | 79.3 | 31.3 – 211.0 | 371 |
| BSA (Meters Squared) | 1.9 | 0.3 | 1.9 | 1.2 – 3.0 | 371 |
| CrCl (mL/min) | 66.3 | 35.5 | 59.6 | 7.9 – 216.2 | 371 |
Demographics from each patient's most recent Vancomycin fitting snapshot.
N = 371 Mean = 58.7 mL/min/1.73 m² (SD 29.8, range 7.9–183.3)
| Stage | Category | CrCl Range (mL/min/1.73 m²) | N | % |
|---|---|---|---|---|
| G1 | Normal / High | ≥ 90 | 51 | 13.7% |
| G2 | Mildly Decreased | 60–89 | 120 | 32.3% |
| G3a | Mildly–Moderately Decreased | 45–59 | 64 | 17.3% |
| G3b | Moderately–Severely Decreased | 30–44 | 69 | 18.6% |
| G4 | Severely Decreased | 15–29 | 57 | 15.4% |
| G5 | Kidney Failure | < 15 | 10 | 2.7% |
Normalised CrCl = CrCl × 1.73 / BSA, using the fitting-time snapshot values.
N = 371 Mean BMI = 28.7 (SD 8.7, range 11.8–68.6)
| Category | BMI Range | N | % |
|---|---|---|---|
| Underweight | < 18.5 | 28 | 7.5% |
| Normal | 18.5–24.9 | 103 | 27.8% |
| Overweight | 25–29.9 | 107 | 28.8% |
| Obese | 30–<40 | 99 | 26.7% |
| Morbid Obesity | ≥ 40 | 34 | 9.2% |
BMI computed from pt_weight / (pt_height × 0.0254)² using the fitting-time snapshot.
| Parameter | Fitted (individual) | Population | ||||||
|---|---|---|---|---|---|---|---|---|
| Mean | SD | Median | Range | N | Mean | SD | Range | |
| Vd (L) | 52.693 | 21.370 | 48.279 | 8.310 – 160.630 | 494 | 55.343 | 19.526 | 20.350 – 137.150 |
| Vd (L/kg) | 0.614 | 0.102 | 0.631 | 0.238 – 1.176 | 494 | 0.650 | 0.000 | 0.650 – 0.650 |
| Cl (L/hr) | 3.9845 | 2.2728 | 3.3903 | 0.3801 – 12.5357 | 494 | 3.7270 | 2.0537 | 0.3146 – 12.0612 |
| Ke (hr⁻¹) | 0.0818 | 0.0470 | 0.0728 | 0.0091 – 0.2923 | 494 | 0.0679 | 0.0312 | 0.0088 – 0.2013 |
| T½ (hr) | 12.15 | 9.05 | 9.52 | 2.37 – 76.31 | 494 | 12.99 | 7.85 | 3.40 – 78.70 |
| Model Fit Bias — Fitted vs. Population Prior | |||||
|---|---|---|---|---|---|
| Parameter | MPE% | MAPE% | RMSE | rRMSE% | N |
| Vd (L) | 9.2% | 13.4% | 8.83 | 24.4% | 494 |
| Vd (L/kg) | 9.2% | 13.4% | 0.108 | 24.4% | 494 |
| Cl (L/hr) | -3.1% | 18.4% | 0.9864 | 26.0% | 494 |
| Ke (hr⁻¹) | -7.0% | 26.0% | 0.03496 | 34.3% | 494 |
| T½ (hr) | 20.8% | 33.4% | 4.85 | 47.9% | 494 |
MPE% (Mean Prediction Error): 1/n ∑[(Population − Fitted) / Fitted × 100%] — positive = population overpredicts individual fit; negative = population underpredicts; near zero = well-calibrated model. MAPE% (Mean Absolute Prediction Error): average magnitude of deviation regardless of direction — lower is better. RMSE (Root Mean Square Error): in the parameter's native units (L, L/hr, hr⁻¹, hr) — measures absolute spread of individual fits around the population prior. rRMSE% (Relative RMSE): RMSE normalised by the fitted value × 100% — scale-independent. MPE%: ■ <20%: best ■ ≤30%: acceptable ■ >30%: caution — MAPE%: ■ <30%: best ■ ≤50%: acceptable ■ >50%: caution — rRMSE%: ■ <50%: best ■ ≤70%: acceptable ■ >70%: caution.
Per-fit individual (post-Bayesian fit) prediction error regressed against patient weight and BMI. N = 494 fits.
| BMI category | N fits | Mean MPE % | Mean MAPE % | Mean RMSE (mg/L) |
|---|---|---|---|---|
| Underweight (<18.5) | 41 | 2.34 | 3.84 | 0.565 |
| Normal (18.5–24.9) | 127 | -0.24 | 3.51 | 0.630 |
| Overweight (25.0–29.9) | 143 | 0.49 | 2.85 | 0.444 |
| Obese (30.0–39.9) | 136 | 0.58 | 2.93 | 0.491 |
| Morbid (≥40) | 47 | 0.23 | 2.88 | 0.533 |
Per-fit individual (post-Bayesian fit) prediction error regressed against BSA-normalised CrCl (mL/min/1.73 m²). N = 494 fits.
| CKD stage | N fits | Mean MPE % | Mean MAPE % | Mean RMSE (mg/L) |
|---|---|---|---|---|
| G1 — Normal (≥90) | 66 | 0.23 | 3.11 | 0.534 |
| G2 — Mildly Decreased (60–89) | 159 | 0.71 | 2.50 | 0.371 |
| G3a — Mild–Moderate (45–59) | 90 | 0.64 | 3.07 | 0.480 |
| G3b — Moderate–Severe (30–44) | 93 | 0.48 | 3.20 | 0.521 |
| G4 — Severely Decreased (15–29) | 74 | -0.82 | 4.00 | 0.767 |
| G5 — Kidney Failure (<15) | 12 | 4.70 | 6.15 | 1.327 |
Pairs a saved dosing recommendation (Predicted) with the fitted peak/trough/AUC₂₄ computed at the patient's next fitting (Achieved). Dose Match indicates both the recommended dose (within 1 mg) and dosing interval (within 0.1 hr) matched the active regimen at the next fitting.
| Parameter | N Pairs | MPE% | MAPE% | RMSE | rRMSE% | Mean Achieved (95% CI) |
|---|---|---|---|---|---|---|
| Peak (mg/L) | 128 | 5.1% | 12.6% | 7.25 | 19.9% |
35.91
(32.62 to 39.20) |
| Trough (mg/L) | 128 | 4.7% | 17.0% | 5.85 | 27.1% |
16.61
(13.53 to 19.70) |
| AUC₂₄ (mg·h/L) | 128 | 4.2% | 12.7% | 145.8 | 18.7% |
593.5
(516.8 to 670.2) |