MP Model (Vancomycin): 268 fits, generated 2026-07-21 14:22 UTC
by marshall.
Two-Compartment Models: 260 fits, generated 2026-07-21 14:23 UTC.
This page displays key performance metrics from institutional pharmacokinetic modeling datasets.
Identical metrics computed across all 1-compartment fittings for comparison with the Goti 2-compartment results above.
Identical metrics computed across all 1-compartment fittings for comparison with the Carreno 2-compartment results above.
N = 260 % Male = 55.0% (n = 260 with sex recorded)
| Variable | Mean | SD | Median | Range | N |
|---|---|---|---|---|---|
| Age (yr) | 66.1 | 16.6 | 67.5 | 22.0 – 99.0 | 260 |
| Height (in) | 67.2 | 4.4 | 67.0 | 56.0 – 77.0 | 260 |
| Weight (kg) | 84.0 | 29.2 | 78.5 | 31.3 – 211.0 | 260 |
| BSA (Meters Squared) | 1.9 | 0.3 | 1.9 | 1.2 – 3.0 | 260 |
| CrCl (mL/min) | 64.5 | 34.8 | 58.3 | 7.9 – 216.2 | 260 |
Demographics from each patient's most recent Vancomycin fitting snapshot.
N = 260 Mean = 57.0 mL/min/1.73 m² (SD 29.0, range 7.9–183.3)
| Stage | Category | CrCl Range (mL/min/1.73 m²) | N | % |
|---|---|---|---|---|
| G1 | Normal / High | ≥ 90 | 29 | 11.2% |
| G2 | Mildly Decreased | 60–89 | 84 | 32.3% |
| G3a | Mildly–Moderately Decreased | 45–59 | 49 | 18.8% |
| G3b | Moderately–Severely Decreased | 30–44 | 47 | 18.1% |
| G4 | Severely Decreased | 15–29 | 43 | 16.5% |
| G5 | Kidney Failure | < 15 | 8 | 3.1% |
Normalised CrCl = CrCl × 1.73 / BSA, using the fitting-time snapshot values.
N = 260 Mean BMI = 28.6 (SD 8.8, range 11.8–68.6)
| Category | BMI Range | N | % |
|---|---|---|---|
| Underweight | < 18.5 | 19 | 7.3% |
| Normal | 18.5–24.9 | 76 | 29.2% |
| Overweight | 25–29.9 | 74 | 28.5% |
| Obese | 30–<40 | 67 | 25.8% |
| Morbid Obesity | ≥ 40 | 24 | 9.2% |
BMI computed from pt_weight / (pt_height × 0.0254)² using the fitting-time snapshot.
| Parameter | Fitted (individual) | Population | ||||||
|---|---|---|---|---|---|---|---|---|
| Mean | SD | Median | Range | N | Mean | SD | Range | |
| Vd (L) | 51.395 | 19.764 | 47.783 | 8.310 – 117.301 | 346 | 54.686 | 19.004 | 20.350 – 137.150 |
| Vd (L/kg) | 0.609 | 0.105 | 0.628 | 0.238 – 1.176 | 346 | 0.650 | 0.000 | 0.650 – 0.650 |
| Cl (L/hr) | 3.9660 | 2.2853 | 3.3468 | 0.3801 – 10.5249 | 346 | 3.6612 | 2.0222 | 0.3146 – 10.7593 |
| Ke (hr⁻¹) | 0.0822 | 0.0475 | 0.0728 | 0.0091 – 0.2923 | 346 | 0.0666 | 0.0299 | 0.0088 – 0.2013 |
| T½ (hr) | 12.18 | 9.27 | 9.52 | 2.37 – 76.31 | 346 | 13.16 | 7.97 | 3.40 – 78.70 |
| Model Fit Bias — Fitted vs. Population Prior | |||||
|---|---|---|---|---|---|
| Parameter | MPE% | MAPE% | RMSE | rRMSE% | N |
| Vd (L) | 10.4% | 14.3% | 8.93 | 26.0% | 346 |
| Vd (L/kg) | 10.4% | 14.3% | 0.113 | 26.0% | 346 |
| Cl (L/hr) | -3.4% | 19.9% | 1.0679 | 28.7% | 346 |
| Ke (hr⁻¹) | -8.0% | 27.7% | 0.03710 | 36.9% | 346 |
| T½ (hr) | 23.7% | 36.2% | 5.22 | 51.4% | 346 |
MPE% (Mean Prediction Error): 1/n ∑[(Population − Fitted) / Fitted × 100%] — positive = population overpredicts individual fit; negative = population underpredicts; near zero = well-calibrated model. MAPE% (Mean Absolute Prediction Error): average magnitude of deviation regardless of direction — lower is better. RMSE (Root Mean Square Error): in the parameter's native units (L, L/hr, hr⁻¹, hr) — measures absolute spread of individual fits around the population prior. rRMSE% (Relative RMSE): RMSE normalised by the fitted value × 100% — scale-independent. MPE%: ■ <20%: best ■ ≤30%: acceptable ■ >30%: caution — MAPE%: ■ <30%: best ■ ≤50%: acceptable ■ >50%: caution — rRMSE%: ■ <50%: best ■ ≤70%: acceptable ■ >70%: caution.
Per-fit individual (post-Bayesian fit) prediction error regressed against patient weight and BMI. N = 346 fits.
| BMI category | N fits | Mean MPE % | Mean MAPE % | Mean RMSE (mg/L) |
|---|---|---|---|---|
| Underweight (<18.5) | 28 | 2.70 | 4.41 | 0.675 |
| Normal (18.5–24.9) | 96 | -0.49 | 4.29 | 0.784 |
| Overweight (25.0–29.9) | 96 | 0.75 | 2.64 | 0.388 |
| Obese (30.0–39.9) | 94 | 0.54 | 3.05 | 0.487 |
| Morbid (≥40) | 32 | 0.14 | 2.29 | 0.397 |
Per-fit individual (post-Bayesian fit) prediction error regressed against BSA-normalised CrCl (mL/min/1.73 m²). N = 346 fits.
| CKD stage | N fits | Mean MPE % | Mean MAPE % | Mean RMSE (mg/L) |
|---|---|---|---|---|
| G1 — Normal (≥90) | 38 | 0.45 | 3.53 | 0.611 |
| G2 — Mildly Decreased (60–89) | 116 | 0.65 | 2.75 | 0.411 |
| G3a — Mild–Moderate (45–59) | 67 | 0.90 | 3.20 | 0.471 |
| G3b — Moderate–Severe (30–44) | 61 | 0.42 | 2.91 | 0.448 |
| G4 — Severely Decreased (15–29) | 55 | -1.43 | 4.27 | 0.826 |
| G5 — Kidney Failure (<15) | 9 | 6.12 | 7.71 | 1.638 |
Pairs a saved dosing recommendation (Predicted) with the fitted peak/trough/AUC₂₄ computed at the patient's next fitting (Achieved). Dose Match indicates both the recommended dose (within 1 mg) and dosing interval (within 0.1 hr) matched the active regimen at the next fitting.
| Parameter | N Pairs | MPE% | MAPE% | RMSE | rRMSE% | Mean Achieved (95% CI) |
|---|---|---|---|---|---|---|
| Peak (mg/L) | 91 | 6.9% | 13.3% | 6.96 | 21.4% |
35.30
(31.37 to 39.23) |
| Trough (mg/L) | 91 | 6.2% | 18.3% | 5.08 | 29.6% |
16.01
(12.54 to 19.48) |
| AUC₂₄ (mg·h/L) | 91 | 5.7% | 13.5% | 130.2 | 19.6% |
578.7
(489.9 to 667.6) |